Karl Friedrich (9 January 1724 – 20 December 1785) was a member of the House of Hohenzollern and Prince of Hohenzollern-Sigmaringen, Lord of Haigerloch and Wehrstein from 1769 until his death.
Born in Sigmaringen, he was the eldest son of Joseph Friedrich Ernst, Prince of Hohenzollern-Sigmaringen and his first wife, Maria Franziska Louise of Oettingen-Spielberg.
From the nine children that his father produced in his first and second marriage, only Karl Friedrich and a young full-sister, Maria Johanna (who became a nun) survived to adulthood.
He returned to Sigmaringen in 1746 and soon parted on the customary Grand Tour (a kind of educational trip) through Germany, Austria and Italy.
On 2 March 1749 at the Kail Castle, Karl Friedrich married with his first-cousin Johanna Josephina Antonia (14 April 1727 – 22 February 1787), a daughter of Count Franz Wilhelm of Hohenzollern-Berg.