Frederick III, Prince of Salm-Kyrburg (Frederick John Otto Francis Christian Philip; 1744–1794) was the prince of Salm-Kyrburg, Hornes and Overijse, Gemen and Count of Solre-le-Château.

He was the eldest son of Philip Joseph, Prince of Salm-Kyrburg and Princess Maria Theresa of Hornes, and he grew up at the French court.

Frederick III was many times confused with a relative Johann Friedrich von Salm-Grumbach who also was styled as Rhinegrave of Salm.

[1] In 1794, he was guillotined together with Alexandre de Beauharnais, the lover of his sister Amalie Zephyrine van Salm-Kyrburg, for their ties with the "Ancien Régime".

Henry Hope wanted to copy the Hôtel de Salm in Haarlem, for his Villa Welgelegen.