He received his education at the universities of Berlin, Vienna, and Breslau, graduating in 1868.

In 1884, he was appointed professor of pathological anatomy at the Senkenbergsche Stiftung in Frankfurt am Main, and received the title of "Geheimer Medizinal-Rat" in 1899.

[1] Weigert assisted Cohnheim in many of his researches, and wrote much on the staining of bacteria in microscopy.

[2] He is credited with the discovery of vascular tuberculosis, and was the first to demonstrate how tuberculous material could enter the bloodstream.

Among his works are: The Weigert-Meyer Rule describes the anatomic relationship of two ureters in a duplicated renal collecting system, as well as the resulting patterns of hydronephrosis, obstruction, and reflux.