Karl von Trier (c. 1265 – 12 February 1324) was a German commander who served as the 16th Grand Master of the Teutonic Order from 1311 to 1324.
During the 1290s he administered the office of Komtur for both German and French bailiwicks (Champagne, Lorraine, and Burgundy).
In 1304 he took on the office of Großkomtur and in this capacity became the representative in Venice of Grand Master Siegfried von Feuchtwangen.
There were disputes among the order's leaders led by Komtur Otto von Lutterberg and Grand Hospitaller Friedrich von Wildenberg which led to a special assembly of the order's capitulum which forced him to resign and caused him to leave Prussia in 1317.
On March 12, 1318, Karl accepted the position of Grand Master again during a general meeting in Erfurt, although he did not return to Prussia.