She is best known for her roles in the film Blue Story (2019) and the ITVX period drama The Confessions of Frannie Langton (2022).

[5] Spence made her television debut in 2018 when she played Amber in the BBC Three short-form sitcom Wannabe.

[9] The limited series premiered on ITVX in December 2022 and in March 2023 on britbox and she has received critical acclaim for her performance.

[10] In April 2022, Spence made her professional stage debut in House of Ife at Bush Theatre.

In October 2023 it was announced she was cast in The Count of Monte Cristo alongside Sam Claflin as Haydée.