It served as a part of the Stockholm commuter rail network from its opening in 1882 until its closure on 10 July 2017.

The station was built alongside the construction of the Värtabanan railway, which connected Karlberg to Värtahamnen via Tomteboda.

Significant modernisation occurred in the early 1970s after Storstockholms Lokaltrafik (SL) assumed responsibility for commuter rail services.

[4] At its peak in 2013, Karlberg handled approximately 14,200 boardings and 14,700 alightings daily, making it one of Stockholm's busiest stations.

[5] Karlberg featured two island platforms, one serving northbound and the other southbound commuter trains.