Karlsruhe (/ˈkɑːrlsruː/ KARLSS-roo) is a city in McHenry County, North Dakota, United States.

Old Saints Peter and Paul Cemetery, Wrought-Iron Cross Site, in or near Karlsruhe, is listed on the National Register of Historic Places.

Peter and Paul Catholic Church in Karlsruhe features works by the artist Count Berthold von Imhoff.

Karlsruhe was first settled in the late 19th century by German pioneers moving toward northern American prairie lands.

These pioneers and their early generations of relatives are buried in the St. Peter and Paul cemetery.

[6] According to the United States Census Bureau, the city has a total area of 0.75 square miles (1.94 km2), all land.

[8] McHenry County has a higher number of natural disasters (24) than North Dakota's state average (12).

There were 19.2% of families and 26.0% of the population living below the poverty line, including 34.6% of under eighteens and 28.6% of those over 64.