Karlsruher SC Amateure first made an appearance in the highest league of northern Baden when it won promotion to the tier three Amateurliga Nordbaden in 1961.

The team continued to generally achieve good results in the league but came only ninth in 1977–78 when a top five finish was required to qualify for the new Oberliga Baden-Württemberg and instead had to enter new the tier four Verbandsliga Nordbaden.

[2][3] The team entered a more successful era from 1994 onwards, now fluctuating between the Oberliga and the newly established Regionalliga Süd.

KSC Amateure won the Oberliga for a second time in 1996 and earned promotion to the Regionalliga Süd, where it played for the next four seasons as a mid-table side.

The team qualified for the DFB-Pokal for a third time for 1996–97 and experienced its greatest success in the competition that season when it reached the third round where it was knocked out by VfL Bochum.

[8] After fans' initiatives, KSC reopened its second team for 2019–20 and entered the Kreisklasse C, the lowest level of league football in North Baden.