In addition to the domestic league, Karlsruher SC participated in this season's edition of the DFB-Pokal, being eliminated in the first round.

The season covers the period from 1 July 2020 to 30 June 2021.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Source: Kicker The league fixtures were announced on 7 August 2020.