Karma Thutob Namgyal (Tibetan: ཀར་མ་མཏའུ་སྟོབས་རྣམ་རྒྱལ, Wylie: Kar ma mt'u stobs rnam rgyal; died 17 October 1610) was a prince of the Tsangpa Dynasty that ruled parts of Central Tibet from 1565 to 1642.
Sakya Dorje performed a protective ceremony and made a talisman for Karma Thutob Namgyal in order to ensure the continuation of his line.
Ponsa Yargyabpa, a Yargyab princess who was the consort of the ruler, became pregnant and gave birth to Karma Phuntsok Namgyal (1587–1620).
However, the main force in the dynasty was the third brother Karma Tensung (d. 1609 or 1611) who led successful military expeditions against Ü (East Central Tibet).
[4] It was his son Karma Phuntsok Namgyal who became the real founder of Tsangpa's power over Central Tibet in the early 17th century.