[1][2] Karmatron depicts the adventures of an extraterrestrial humanoid called Zacek ("White Star" in Maya language), emperor of the alien Zuyua people and also a Kundalini warrior that an ancient prophecy announced to be the one who could restore the balance between light and darkness in the universe.

Zacek was the bearer of the powerful Kalpe-Om, a magical belt that allowed him to transform himself into Karmatron, a 300 feet tall armoured spiritual warrior.

[2] The story starts millions of years ago, in a very distant place in the universe—Planet Zuyua—where Zacek lived peacefully as the youngest of two heirs to the Zuyuan throne.

However, while zuyuan strategists planned an escape route from Planet Zuyua, emperor Canilek sent his two sons on a quest to seek the Planet of Eternity, a sacred, mystical place where spiritual warriors go to attempt to awake the Kundalini serpent that lived in Mount Meru, and thus gain the spiritual transcendence, wisdom, inner peace and power that comes with being a Kundalini.

Meanwhile, Zacek and his older brother Nazul arrived at the Planet of Eternity, but as they reached the sacred serpent's chamber located in the depths of Mount Meru, a metnalian soldier who followed them by Asura's command assaulted the two princes (Asura knew of the prophecy of the Kundalini that would defeat him) and managed to grab Nazul and take him to his ship before he could go into the serpent's resting place.

Zacek was unable to help his brother, because the heavy slab of stone that guarded the serpent's chamber entrance slammed shut in that precise moment, trapping him in there.

The zuyuan prince underwent the difficult task of awakening the sacred serpent, a feat that only the most spiritually enlightened and pure of heart could accomplish.

Asura caught a glimpse of this awesome steel giant that came to his planet, and he became violently enraged then, for he acknowledge him for what he was, and knew him to be the source of many future problems.

As Karmatron, Zacek has all his Kundalini powers enhanced by a tenfold (or more), he has super-strength, near physical invulnerability, the ability to fire a variety of types of rays and bolts, he has flight capability, he can survive in space or in any environment short of a nuclear inferno (which almost killed him once) and he can shrink to microscopic level.

According to González Loyo most of the main characters, the basic concept and plot of Karmatron were created as early as 1978, but the lack of interested publishers pushed back the release of the comic for several years.

In 1992 a new reboot edition was released in a black and white graphic novel format with redesigned characters, but this was a special limited series that lasted just a couple issues.

Studio with a modified storyline, new art, improved modern digital coloring, new designs and a bigger, more standard comic book size format.

[7][6] From number 284 to 286 -published in 1991- another crossover called "Aventuras en el Planeta Tier-rata" (Adventures in Planet Earth-Rat or Adventures in Planet Terrat) took place, where the protagonists were Jiva and Robby (Karmatron sidekicks and comic relief characters from Oscar González Loyo) as well as Visitor Zot and rats Fulano, Zutano and Mengano (from an indie comic by artist and author Francisco "Paco" Baca).

However, as the storyline progressed and the philosophical ideas exposed and the mysticism turned more dense and evident, both the editorial and the public became more and more alienated until the comic ceased to be published in the early nineties.