Karnak is a village in Pulaski County, Illinois, United States.

[3] The village, which resides in the Little Egypt region, was named after the Karnak temple site.

[6] As of the census[8] of 2000, there were 619 people, 263 households, and 174 families residing in the village.

The racial makeup of the village was 93.70% White, 5.49% African American, 0.16% Asian, 0.65% from other races.

30.0% of all households were made up of individuals, and 16.7% had someone living alone who was 65 years of age or older.