Grand Chain is a village in Pulaski County, Illinois, United States.

There were 121 housing units at an average density of 114.3 per square mile (44.1/km2).

The racial makeup of the village was 90.99% White and 9.01% African American.

34.3% of all households were made up of individuals, and 15.2% had someone living alone who was 65 years of age or older.

About 21.7% of families and 21.5% of the population were below the poverty line, including 32.4% of those under the age of eighteen and 15.0% of those 65 or over.