Karnali Zone (Nepali: खसान अञ्चलListenⓘ) was one of the fourteen zones located in the Mid-Western Development Region of Nepal.

Karnali Zone was one of the poorest and most remote regions of Nepal, not very accessible by road yet.

There are airfields in all districts except Kalikot which is connected seasonally by roadways to Jumla Airport.

Shey Phoksundo National Park Shey Phoksundo (with Phoksundo Lake—the deepest lake of Nepal), famous for the snow leopard, is Nepal's largest park with an area of 3,555 km2.

This article about a location in Karnali Province of Nepal is a stub.