The Karoo Desert National Botanical Garden is a botanical garden focused on succulents and other plants of arid regions, that lies at the foot of the Hex River Mountains range, in the town of Worcester, South Africa.

[3] The remainder preserves the natural vegetation of the area, such as the succulents of the unique Robertson Karoo vegetation type, and patches of the threatened Breede Shale Renosterveld vegetation type.

The cultivated area, with its network of pathways, includes a very large succulent collection.

There are another 400 plant species that are naturally indigenous to the garden's premises.

[4] A range of wild animals also naturally occurs in the garden, including the shrub hare, grey mongoose, three tortoises species (Chersina angulata, Stigmochelys pardalis & Homopus areolatus) and a range of other small mammals, reptiles and amphibians.