He belonged to the Human mitochondrial DNA haplogroup H1 and the Y-haplogroup R, and was dated ca 5207-5070 BC, which was the time of the Early-Neolithic Linear Pottery.

BC, the time of the Corded Ware culture (German Schnurkeramik); she belonged to the mitochondrial haplogroup H.[3][4] Saint Lawrence, the patron saint of the Karsdorf village church, and St. Martin of Tours for the church of the defunct village Bünisdorf (also Pinsdorf ) stand for this early origin.

Founded as a Franconian foundation on the old Franconia, Wein- or Kupferstraße Karsdorf is mentioned in 1109 as Karlestorph in a document.

It was built directly on the ford by the Unstrut, to whose protection soon a castle was built on the high ridge, which was initially owned by the Counts of Mansfeld, then passed to the Noble Lords of Querfurt and their legacy after extinction in The second half of the 15th century fell largely to the House of Wettin.

Decisive for the establishment of the town and its further development was the location on the Unstrut and the Unstrutfurt, which existed only a few meters from the present Karsdorfer bridge.

After the devastating fire of 1608, which fell victim to 117 houses "including the beautiful, newly built church, parish, school, mill, brewery, bakery and Keltern", those of Rockhausen gave up their goods lying there.

During the Second World War, many women and men from German-occupied countries had to do forced labor in the cement factory, many of whom died.

The great demand for cement in the GDR led to the plant deactivating its environmental technology, which would have made production more expensive or slower.

Through the Unstruttal bridge, the nearby castle in Burgscheidungen and the Nebra sky disk, tourists are increasingly driving through the town.