It is located in the east of the region, close to the border with Russia, and serves as the administrative center of Kastsyukovichy District.

In the middle of the 19th century it had a population of 1700 and was the administrative center of Kostyukovichskaya Volost of Klimovichsky Uyezd, Mogilev Governorate.

In November 1941, 350 Jews were murdered in a mass execution in the Orthodox cemetery perpetrated by an Einsatzgruppen.

In Kastsyukovichy, there is a cement plant, as well as several enterprises of food industry, including alcohol production.

[5] Kastsyukovichy has a railway station on the railroad connecting Orsha with Unecha via Krychaw.

South of the town, the railroad crosses the state border and enters Russian Federation.