Hamill is known for writing and acting in innovative, contemporary adaptations of classic novels for the stage, including Jane Austen’s Sense and Sensibility, Emma, and Pride and Prejudice; William Makepeace Thackeray’s Vanity Fair; Bram Stoker's Dracula; Louisa May Alcott's Little Women; and Arthur Conan Doyle's Sherlock Holmes stories.
[citation needed] As a playwright, she has a playful and theatrical style that features absurdity while examining social and gender issues.
"[6] Hamill's Sense and Sensibility premiered in a short run at New York City's Bedlam Theater Company in November 2014.
[10][11] Hamill's adaptation of Pride and Prejudice premiered at the Hudson Valley Shakespeare Festival in 2017, directed by Amanda Dehnert.
[3] The production, in which Hamill and her long-term partner, Jason O'Connell, play the leading roles of Elizabeth Bennet and Mr. Darcy, transferred to Manhattan's Primary Stages.
In 2021, Hamill's "cheerful desecration" of Sherlock Holmes stories opened at Kansas City Rep, directed by Jose Zayas.
In 2023, Hamill's original play about the British courtesan Harriette Wilson premiered at Cygnet Theater, directed by Rob Lutfy.