The Kate Shelley 400 was a short-lived streamlined passenger train operated by the Chicago and North Western Railway between Chicago, Illinois and Iowa.

The train drew its name from the CNW's popular Twin Cities 400, so-named for making the 400-mile (644 km) run from Chicago to Minneapolis, Minnesota in 400 minutes, and Kate Shelley, a young woman who in 1881 risked her life to save a passenger train from a washed-out bridge.

[1]: 148  The C&NW introduced the Kate Shelley to fill the void left by the Union Pacific Railroad's famed "City" streamliners, which had moved from the CNW's route to that of the Milwaukee Road.

The Kate Shelley made its first run in October 1955.

The CNW dropped the name altogether on July 23, 1963, though the unnamed trains #1 and #2 continued running until the formation of Amtrak in 1971, when they were discontinued.