In 2006, D'Onofrio appeared on Season 2 of La Gran Sangre as Venus, the leading role that led her to fame.
A member of the group "the evil goddesses", she played the partner of a main character at the time of his death.
[2] In August 2011, she played Leonor in the telenovela La Perricholi [es], a woman born in the Viceroyalty of New Granada.
[3] In 2012–13, D'Onofrio performed in the plays Botella borracha and El sistema solar, the latter by Mariana de Althaus [es].
[4] In 2014, she debuted on the series Mi amor, el wachimán [es] as Lieutenant Angélica.