She is the author and producer of experimental films, videos, and animation series, which focus mainly on subjects related to her country of origin, Greece.

Moutsatsou started training in classical ballet at the age of 6, attending the Royal Academy of Dance registered teachers' program in Athens.

In Greece, she became instantly known to the Greek public in 1996 thanks to her breakthrough comedic role in the main cast of Nico Mastorakis’s parody sitcom, Divorced with Children for Antenna TV.

[6] In 1998, Moutsatsou traveled to Turkey to play the female lead in Biket Ilhan’s Kayıkçı (“Boatman”), the first Turkish-Greek film co-production ever made, alongside Memet Ali Alabora.

[17] After I am Hellene, she produced a series of experimental yet highly political videos which usually focus on Greece,[18] the Greek crisis,[19] and the European Union.

[22] In 2012, she married American producer Charles Como in a civil ceremony in Beverly Hills, followed by a religious wedding in a Greek Orthodox Church in 2017.