[1] Hughes was a member of the comedy sketch group Gein's Family Giftshop, alongside Kiri Pritchard-McLean, Adam Scott-Rowley and Edward Easton.
[7] In 2015, Hughes made her solo acting debut in the BBC black comedy series Inside No.
[9] In 2018, Hughes portrayed Laura in an episode of the Sky Atlantic comedy Sally4Ever and Miriam in the television sitcom Zapped.
[10] In 2019, Hughes appeared as a supermarket checkout assistant in the first series of the Netflix black-comedy drama After Life.
[12][13] Hughes also appeared in an episode of the Channel 4 series The Joy of Missing Out, and the short films Petrichor and Pedwar, the latter of which she co-wrote.