She has been using an industrial paint-sprayer to apply prismatic swaths of color to a variety of surfaces since the late 1990s, and often uses bright, unmixed sprayed-on acrylic paints to create both large-scale sculptural elements and smaller wall works.

[3][2] In subsequent years, she completed artist-in-residence programs at the Villa Romana in Florence, Italy (1992); Chinati Foundation in Marfa, USA (1999);[4] Elam School of Fine Art in Auckland, New Zealand (2001); and Headlands Center for the Arts in San Francisco, USA (2002).

Grosse maintains studios in Berlin's Moabit district (since 2008),[5] Auckland[6] and Groß Kreutz (since 2020).

[13] In this capacity, she was part of the search committee that chose Emma Enderby as the KW's new director in 2023.

[19] In 2005, she purchased a former supermarket in Berlin's Friedrichshain district and turned it into her primary residence.