Katharine MacGregor is an American political advisor and lobbyist who served as the United States Deputy Secretary of the Interior in the final year of President Trump's first term.

She assumed office in February 2020, succeeding David Bernhardt, who was confirmed as Secretary of the Interior.

[1] In January 2025, President-elect Trump announced his intention to nominate MacGregor as Deputy Secretary of the Interior again for his second term.

[2] MacGregor earned a Bachelor of Arts degree in history and classical studies from the University of Pennsylvania in 2004.

[3] She worked as a lobbyist and was then a congressional staffer for Thelma Drake and Eric Cantor.