Her father was a knight and would become the 1st Baron Clifton of Leighton Bromswold in Huntingdonshire, England.
[2] Her brother died in 1602 and she became the only surviving child of her parents and heiress of the manor of Leighton Bromswold.
In 1609, when she was about 17, she married her first husband, Lord Esmé Stewart, a younger son of The 1st Duke of Lennox in Scotland.
[9] Two letters sent by Katherine to William Douglas, 7th earl of Morton are preserved in the National Library of Scotland collections.
Her eldest son James succeeded her as Baron Clifton in addition to the titles he inherited from his father.