Wilcox attended The Evergreen State College where she studied film and worked with Tobi Vail at a sandwich shop.

[1] During this time she and friends Kathleen Hanna and Vail collaborated on a feminist zine titled Bikini Kill.

[2] The three women enlisted guitarist Billy Karren and began a feminist punk band also called Bikini Kill.

Wilcox's other musical projects include the Frumpies with Vail, Karren, Michelle Mae (The Make-Up), and Molly Neumann (Bratmobile); The Casual Dots with Christina Billotte (Slant 6, Quixotic) and Steve Dore;[3] and The Julie Ruin with Hanna, Kenny Mellman (Kiki & Herb), Carmine Covelli, and Sara Landeau.

Wilcox collaborated with Fugazi's Brendan Canty on the theme song to the punk rock-oriented children's show Pancake Mountain.