[4] She made her professional debut as a soloist with the Minneapolis Symphony Orchestra conducted by Emil Oberhoffer in 1918.

She sang with the company in the years 1926-1927, 1929, 1932-1933, 1935-36, performing the roles of Azucena in Il trovatore, Brangäne in Tristan und Isolde, The Witch in Hansel und Gretel, Ortrud in Lohengrin, Erda in Das Rheingold and Siegfried, Fricka in Die Walküre and Waltraute in Götterdämmerung.

In 1927 she sang with the Los Angeles Grand Opera, appearing as Amneris as well as Giovanna in Rigoletto and Suzuki in Madama Butterfly.

Her Met career was brief, with a total of eleven performances from 1935 to 1938 in the roles of Azucena, Fricka, Erda and Waltraute.

[9] From her earliest years as a professional singer through 1940, Meisle gave numerous recitals across the country.