In 2004, Lowes landed her first screen role in the FX series Rescue Me and later co-starred opposite Marcia Gay Harden in the Showtime pilot, Hate.

Lowes later guest starred in a number of television series, including The Sopranos, Without a Trace, NCIS, Ghost Whisperer, Castle, Leverage, and The Closer.

Lowes is best known for her role as Quinn Perkins, formerly Lindsay Dwyer, in the ABC political drama series Scandal created by Shonda Rhimes.

[14] On May 14, 2021, CBS announced that Lowes would star opposite Pete Holmes in a sitcom based around the life of laid-off auto worker-turned-professional bowler Tom Smallwood.

Lowes played Rachel DeLoache Williams in Shonda Rimes' Inventing Anna, a Netflix miniseries released in February 2022.