In the heart of North Macedonia's wine country, it is home to the largest winery in Southeast Europe,[1] named after the Tikveš plain.

Bronze and ceramic artefacts were discovered at an archaeological site in the nearby town of Stobi (Macedonian: Стоби) dating to the 6th and 7th century BC.

This town is said to have been established during the Hellenic period; being on the main road of Via Egnatia that led from the Danube to the Aegean Sea meant it became an important military, economic and cultural hub.

Villagers from Rashtani and Dukena fleeing from the Ottomans settled in a new area, bringing with them many families that exist in Kavadarci today.

Kavadarci was under the jurisdiction of Bitola's area Pashaluk (Ottoman military territorial unit controlled by a Pasha).

The resistance fighters freed the majority of the Tikveš region, including the towns of Kavadarci, Negotino, Vataša, and several small villages.

Recep Vardarlı moved to Turkey and founded Tikveşli ("Came from Tikveş" in Turkish) company, which produces yogurt and ayran, in 1943.

Covering a large area in the Tikveš valley with a total ground surface of 391 km2 (151 sq mi), it comprises 31 settlements, the largest of these being Vataša (Macedonian: Ваташа).

Vineyards in the region cover a total area of 120 square kilometres (46 sq mi), producing up to 85,000 tons of grapes annually.

The tradition of wine making and grape growing in the Tikveš region date as far back as the 4th century BC.

The Tikveš region is in an area with a unique and favourable climate produced by the merging of the Mediterranean from the south and Continental from the north.

Combined with arable soil, high with eroded clay content makes this a most favourable area to grow grapes.

The combined municipalities of Kavadarci and Rosoman use 20% of the North Macedonia’s total landmass (5,142 km2 or 1,985 sq mi) for the cultivation of grapes.

Until 2013, the smelter received at least part of its input ore from the Ržanovo mine [mk],[8] to which it was connected by the world's longest conveyor belt.

[9] The company FENI Industries, with a colourful history of owners that included for a time Beny Steinmetz, Alexander Mashkevich, Patokh Chodiev and Alijan Ibragimov in the Cunico Resources vehicle,[10] produced between 12000 and 16000 tons of ferronickel annually.

[11] In a bid to attract more interest from domestic and foreign investors in 2000 the first Free Economic Zone (FEZ) of North Macedonia was founded in Kavadarci.

During this time the city centre houses many temporary restaurants, stalls and shops open to allow visitors to experience the smells and tastes of local delicacies.

It generates electricity through the use of a hydro power plant (HPP), is a site for sports and recreation, and is a popular tourist attraction due to the cultural monuments and rich flora and fauna of the area.

At that moment a lightning bolt appeared out of the blue sky: Saint Ilija angered by this claim split the new church in half.

The church within the Pološki Monastery is dedicated to Sveti Gorgija (Saint George) and is on the southwestern shore of Lake Tikveš that is accessible only by boat.

The monastery is well known for its collections of unique icons, wood carvings and especially for its fresco art that differ from others of the same period due to its unusual compositions.