Because of its rather high rainfall compared to most other parts of Namibia and its location on the Kavango River after which it was named, this region has agricultural potential for the cultivation of a variety of crops, as well as for organised forestry and agro-forestry, which stimulates furniture making and related industries.

[3] The Fourth Delimitation Commission of Namibia, responsible for recommending on the country's administrative divisions suggested in August 2013 to split the Kavango Region into two.

[6] On 27 April 2014 Sirkka Ausiku, formerly Permanent Secretary of the Ministry of Regional and Local Government, Housing and Rural Development, was appointed.

The interior is very sparsely inhabited, while the northernmost strip, especially along the Kavango River, has a high population concentration.

Environmental activists have expressed concern that ReconAfrica's plans for its test wells have not been properly vetted through Namibia's environmental review process, however ReconAfrica and both the governments of Namibia and Botswana have stated that the company's activities have followed due process and that no fracking will occur.