Kawasaki-ku (川崎区) is one of the seven wards of the city of Kawasaki in Kanagawa Prefecture, Japan.

In the Edo period, it was administered as tenryō territory controlled directly by the Tokugawa shogunate, but administered through various hatamoto, and prospered as Kawasaki-juku, a post station on the Tokaido highway connecting Edo with Kyoto.

After the Meiji Restoration, the area urbanized with the development of Kawasaki Station on the Tokaido Main Line and became a center for heavy industry.

The area was largely destroyed by the Great Kanto earthquake of 1923 and during American bombing during World War II.

Long associated with grime, labor unrest, organized crime and pollution-related diseases, the local government undertook extensive efforts in the 1990s to revamp the area image.