He entered the Royal Danish Academy of Fine Arts in 1909 and while there worked at the offices of leading Scandinavian architects such as Anthon Rosen, Sigurd Lewerentz, Gunnar Asplund, and Hack Kampmann parallel to his studies.

[1] After graduating, his career as a practising architect was dominated by numerous influential residential projects.

[2] A key building in his production was Aarhus University (1931–43), considered to be one of the most important examples of Danish Functionalism, which he designed in collaboration with C. F. Møller, Povl Stegmann, and Carl Theodor Marius Sørensen.

In his writings, Fisker argued in favour of an anonymous and timeless architecture, not fashionable individual achievements.

In the 1964 article "Personal Worship or Anonymity",[3] Fisker emphasized the importance of our surroundings being characterized by a whole - as opposed to simply consisting of a number of individual, sensational works.