He was awarded the Shanti Swarup Bhatnagar Prize for Science and Technology for the year 2019 in Biological Sciences "for his outstanding contributions in the area of structural biology by providing remarkable insights into the functioning of restriction-modification enzymes, which play a crucial role in bacterial defense".
[1][2] Kayarat Saikrishnan secured Ph D in Molecular Biophysics from Indian Institute of Science, Bangalore in 2005 under the supervision of M.
[4] Biological processes involving nucleic acid employ enzymes driven by motors energized by the hydrolysis of nucleoside triphosphate (NTP).
Many of these enzymes which are sometimes referred to as protein machines have modular functional domains that act in concert to carry out a specific task.
Biochemical and single-molecule biophysical studies carried out based on the structure revealed a new mechanism of double-strand DNA-break formation resulting from multiple nicks of the DNA strands.