McBride was a three-year starter and four-year letterwinner at Villa Maria under head coach Scott Dibble, helping Victors to combined record of 106–15 (.876) with two Pennsylvania Class AA state titles (2009, 2010) and a state runner-up finish (2007) in her prep career.

In her freshman year in 2006–07, served as top reserve ("sixth man") on Class AA state runner-up squad that went 27–5; she averaged 6.7 ppg., 4.3 rpg., 1.6 spg.

with a .740 free throw percentage that season and earned Swin Cash award as Western Pennsylvania's Freshman of the Year in 2007.

As a senior in 2009–10, led Villa Maria to a 28–2 record and its second consecutive state championship ... averaged 20.5 ppg., 11.8 rpg.

and 5.6 spg., including 29 points and 11 rebounds in Class AA state final against York Catholic.

McBride owns school records (boys or girls) in career points (1,727), rebounds (931), assists (474), steals (420) and blocked shots (191).

She led the league in free throw percentage, and almost tied ninth in the country but was two made foul shots shy of the minimum to qualify for the national ranking.

She was one of three unanimous selections to the WNBA All-Rookie Team and finished third in Rookie of the Year voting.

McBride scored in double-figures in 21 games, including two 30-point performances, while recording the most points by a Stars rookie (442) since the team relocated to San Antonio.

The Stars achieved a playoff berth and finished third place in the Western Conference but were eliminated by the Minnesota Lynx in a 2-game sweep during the first round.

In the 2016 season, McBride would continue to improve, but suffered a right foot injury on July 2 against the Minnesota Lynx.

By the end of the season, McBride averaged a new career-high in scoring, this performance along with rookie sensation A'ja Wilson would almost lead the Aces back in the playoffs but they fell short finishing 9th place in the league with a 14–20 record.

McBride played and started in all 22 games, the Aces finished 18–4 with the number 1 seed, receiving a double bye to the semi-finals.

In the semi-finals, the Aces would advance to the Finals after defeating the Connecticut Sun in a hard-fought five-game series but would end up getting swept by the Seattle Storm.

"[10] She has also said in 2024 that "I've talked about it since I've been here, Minnesota has been such a saving grace for me and my career...I felt really lost when I was leaving Vegas … and I found a home here very quickly.

[11] In the September 13, 2024, game against the Chicago Sky, McBride became the first Lynx player in franchise history to have 100+ 3-point shots in a single season.

On August 14, 2024, it was announced that McBride would appear and play in the inaugural season of Unrivaled, a new women's 3x3 basketball league founded by Napheesa Collier and Breanna Stewart.

The team won all five games, earning the gold medal for the event, and a place in the 2011 U19 World Championship for women.