[5] Kaneshiro began her career as a model when she was seven years old for clothing brands like Ralph Lauren walking runways and doing print ads.
[7] She went to appear on shows like American Horror Story, Santa Clarita Diet, The Real O'Neals, and Kickin' It among others.
[8][9] Her first lead role was in the 2014 independent film in Mary Loss of Soul.
In 2018, Kaneshiro was cast in The CW's supernatural drama series Legacies as Josie Saltzman, one of the series' starring roles,[10] a role she portrayed on the show through its fourth season.
[12] On November 30, 2023, she announced on Instagram that she would no longer be using the stage surname "Bryant" she'd chosen as an 11-year old, and would be henceforth go by her birthname "Kaylee Kaneshiro.