In 1990 she became part of the Nordik beat scene and released a self-titled club-soul influenced album on The SweMix Label.

After acting in a couple of teenage movies in the mid-1990s, she became one-half of Le Click, who had several hit singles in North America and Germany during the 1990s.

Kayo Shekoni has also hosted Förkväll[2] on TV4 and Fångarna på fortet ( the latter with cross-country skiing star Gunde Svan).

directed by Josette Bushell-Mingo,[8] “Raisin in the Sun” with the National Theatre (and touring with the play in Sweden and Finland, and taking the production to South Africa and the US),[9][10] Norrbottens Teatern's production of “Cabaret”, "The Witches of Eastwick" (the latter with West End star Peter Jöback),[11] "Taube Today" at Västmanlands Teater and Uppsala Stadsteater.

In 2023, Shekoni is part of the main jury panel along with Swedish actor, performance artist, playwright and drag queen Robert Fux and radio and television host Farao Groth of the Swedish language reality television series Drag Race Sverige broadcast on SVT1 and SVT Play in Sweden and internationally on WOW Presents Plus.