It is located 26.8 km from the eastern terminus of the Izumi Line at Ōhara Station, and 39.1 km from the western terminus of the Kominato Line at Goi Station.

Kazusa-Nakano Station has two side platforms, each serving bidirectional traffic; one platform is for the Isumi Line, and the other for the Kominato Line.

[1] On August 26, 1934, the Japanese Government Railway (JGR) Kihara Line, the predecessor of the Isumi Line, began operations from Kazusa-Nakano Station.

[1] The Kihara Line became part of the Japanese National Railways (JNR) after World War II, and freight operations were discontinued from October 1, 1974.

With the division and privatization of the Japan National Railways on April 1, 1987, the Kihara Line was acquired by the East Japan Railway Company and was renamed the Isumi Line on March 24, 1988.