Kazusa-Ōkubo Station (上総大久保駅, Kazusa-Ōkubo-eki) is a railway station operated by the Kominato Railway Company's Kominato Line, located in Ichihara, Chiba Prefecture, Japan.

It is 32.3 kilometers from the western terminus of the Kominato Line at Goi Station.

Kazusa-Ōkubo Station was opened on May 16, 1928.

Kazusa-Ōkubo Station has a single side platform serving bidirectional traffic.

There is a small rain shelter built on the platform, but no station building.