She has shared arenas with both local and international artists, including: Eve, Sibongile Khumalo, Busta Rhymes, Beyonce, Prime Circle, Ashanti, Dwele and Brandy.
She began her musical career when she joined the South African group, Crowded Crew, who became prominent in the late 1990s.
In 2001, Motsilanyane joined the e-TV soapie Backstage as herself; this coincided with the release of her debut album, Beautiful Vibrations (2002), which featured the hit song "O A lla", earning her the name Mamosadi.
After her departure from the show, she played the role of Lucilla Vilakazi in the popular television series Rhythm City.
In 2017, she joined the popular South African Afrikaans soapie 7de Laan and played the role of a feisty lawyer, Lesedi.