"[2] His post-modern blues style is influenced by many eras and genres, including folk, rock, jazz, pop and country.

The moniker "Keb Mo" was coined by his original drummer, Quentin Dennard, and picked up by his record label as a "street talk" abbreviation of his given name.

From early on, Keb' Mo's parents, who were from Louisiana and Texas, instilled in him a great appreciation for the blues and gospel music.

[citation needed] Keb' Mo' started his musical career playing the steel drums in a calypso band.

Keb' Mo's first gold record was received for a song, "Git Fiddler", which he co-wrote with Creach on Jefferson Starship's Red Octopus.

Moore jammed with Albert Collins and Big Joe Turner and emerged as an inheritor of a guarded tradition and as a genuine original.

Keb' Mo' has appeared on stage (1990–1993) in several versions of the musical Spunk, by George C. Wolfe, an adaptation of three short stories by Zora Neale Hurston.

Keb' Mo's self-titled album was released on Okeh Records, a vintage revival division of Sony Music.

He won his first Grammy Award for this album, which featured guest appearances from Jackson Browne and Bonnie Raitt.

He joined musicians Laval Belle on drums, Reggie McBride playing bass and Joellen Friedkin on keyboards to perform 14 songs, some from each of his albums.

In 1998, Moore was involved in the multi-artist project "Begegnungen (Encounters)" by German rock musician Peter Maffay.

His touring band following the release included Reggie McBride on bass, Les Falconer III on drums, Jeff Paris on keyboards, and Clayton Gibb on guitar.

[13] In May, he appeared alongside Metallica at MusicCare' 10th Annual MAP Fund Benefit Concert at Nokia honoring Ozzy Osbourne and Jeff Greenberg.

[17] He has been supportive of charity Playing For Change since its inception and recently appeared in a video with Keith Richards' singing Bob Marley's "Get Up, Stand Up".

The album had over 180 musicians from 31 countries, including Keith Richards, Sara Bareilles, David Hidalgo, Cesar Rosas, and Taj Mahal.

Other performers included Smokey Robinson, James Taylor, Buddy Guy, Queen Latifah, Usher, Trombone Shorty, MC Lyte, Audra McDonald, Esperanza Spalding, Brian Stokes Mitchell and Carol Burnett.

[23] The album has guest appearances by Bonnie Raitt, Joe Walsh, Sheila E., and Lizz Wright, and has six original compositions and five covers, from artists and bands like John Mayer and The Who.

[25] In June 2019, Keb' Mo' released a studio album, Oklahoma, with guest contributions from Rosanne Cash, Jaci Velasquez, Robert Randolph, and Taj Mahal, with a duet with Robbie Brooks Moore (his wife).

[30] In 2019, Keb' Mo' featured as a guest artist on the PBS concert series Bluegrass Underground (now re-branded as The Caverns Sessions).

In 2004, he participated in the politically motivated Vote for Change tour alongside Bonnie Raitt and Jackson Browne, with whom he originally recorded the title track from the album Just Like You.

Two years later, he appeared on Amy Grant: Greatest Hits 1986–2004 in a duet entitled "Come Be with Me", which became a modest success on pop radio.

Moore appeared on the June 7, 2008, broadcast of Garrison Keillor's radio program A Prairie Home Companion.

The proceeds of the album benefited The Eric Lowen Trust, ALS Association Greater Los Angeles, and Augie's Quest.

Moore sings the opening theme ("I See Love", which he co-wrote with Josh Kelley) to the CBS sitcom Mike & Molly.

Moore produced and co-wrote the song "Diggin' in the Deep Blue Sea" on the 2011 David Bromberg album Use Me.

In 2017, he appeared in “Signed, Sealed, Delivered: Higher Ground” (Hallmark Mystery Movie series) as the character Gabe, and performed several songs.