The house and its exact location are unknown but the starting point for Gordon's Purchase was on today's Bell Lane.

[6] As more settlers moved into the region a grist mill was built on Little Antietam Creek about 1765 to serve the earliest farmers who were mostly German and Swiss immigrants who'd migrated from Pennsylvania.

In the years immediately following Jacob Hess's death the Sharpsburg to Boonsboro Turnpike was constructed (about 1820), which became Keedysville's main street.

The town's name officially became Keedysville when the first post office was established due to the existence of another Centerville, Maryland in Queen Anne's County.

In the mid-1860s the B&O Railroad began acquiring a right-of-way and by the early 1870s a branch line extended from Weverton to Hagerstown with a busy Keedysville depot as the mid-way point.

Keedysville was home to numerous businesses through the first half of the 1900s but the commercial nature of the town had begun to decline by the century's second decade.

Like most small towns, the advent of the automobile and mechanization brought a gradual change as larger stores and factories became easily accessible and previously plentiful manual labor jobs decreased.

Several additions to the town were planned by the turn of the century and the population which had previously hovered around 400 for many years, suddenly swelled to more than double that number in a single decade.

An alternate history credits Jacob Hess as the first settler, who then builds a mill forming the nucleus for the town.

[10] According to the United States Census Bureau, the town has a total area of 0.92 square miles (2.38 km2), all land.

The area was once home to eight different caves, several of which were discovered during quarrying operations to remove rock for highway construction.

The water table in this locality is drained by the Little Antietam Creek and its tributaries, and many of these caves can be found in the cliffs and along the broken plateau east of town.

The climate in this area is characterized by hot, humid summers and generally mild to cool winters.

The only significant highway serving the town is Maryland Route 34, which connects eastward to Boonsboro and westward to Sharpsburg.