Keene is a home rule-class city located in Jessamine County, Kentucky, in the United States.

The U.S. Census Bureau does not record Keene as a city and does not publish a population figure for the community.

The community grew up around a stone mill erected in 1794 and was originally laid out as North Liberty in 1813.

In 1830, however, the first postmaster, Ephraim Carter, named his new post office after Keene, New Hampshire, the hometown he shared with local store owner Harvey Huggins.

The climate in this area is characterized by hot, humid summers and generally mild to cool winters.