The show begins with an introduction from Defries, who then lets four contestant teams of two best friends (dressed in blue, pink, purple, and silver shirts) out of "The Mixer" (a large carousel-like contraption at the center of the platform on the set).
Each pair of contestants explains why they are best friends before playing the first game of the show, Tube Strike.
Before the next challenge, Defries explains how the main game works: the eight contestants are randomly split into four groups of "frenemies" - pairs of contestants from different teams - by The Mixer, and then compete with one another in a challenge, typically a race to complete an objective.
The last remaining pair is allowed to remove their teammates from Lockdown and will move on to the final round.
The team who is playing will have five seconds to come up and say two correct answers - items within that category that start with the illuminated letter.