During the 1970s, Milow was considered part of the British artistic avant-garde along with artists such as Richard Long, Gilbert & George, Michael Craig-Martin, Mark Lancaster, Tim Head, Nicholas Pope, John Walker, David Tremlett, Barry Flanagan, Art & Language and Derek Jarman.

Often his work is the result of a direct response to other artists' oeuvres, notably the Dutch painter Piet Mondrian.

In 2015, he was nominated for the Charles Wollaston Award of the Royal Academy Summer Exhibition and in 2017 for the Daiwa Foundation Art Prize.

[4] In 1970 Keith Milow had his first solo show with Nigel Greenwood Gallery, an exhibition that sold out with Tate being one of the buyers.

An important commission of 1998 was the piece 20th Century – Thames, consisting of four large tondi in the lobby of One Canada Square (Canary Wharf, London).