[3] Former series Head Writers include Neil McCarthy, Mitzi Booysen, Ilse van Hermert, Christian Blomkamp, Busisiwe Ntintili, Loyiso Maqoma, Liam J Stratton, Rosalind Butler, Rohan Dickson, Bongi Ndaba, and Duduzile Zamantungwa Mabaso.

The main characters include the Haines family, the Matabanes, Vusi Moletsane the mine manager and the various residents of the boarding house owned by Maggie Webster.

Barker Haines, owner of ON TV, is a high-living billionaire who often schemes his way into the lives of various people in and out of the mining town of Horizon Deep, notably his daughter Leone.

[7] Six months after Callie's death, the series killed off original character Letti Matabane (played by actress Lesego Motsepe) in a similar car accident, prompting a "nationwide outpouring of grief".

The show's executive producer Pumla Hopa explained how Isidingo was different from other soapies at the time: "The thing that sets us apart is that we deal with issues in society from homosexuality, xenophobia, mixed marriages and HIV-Aids.