He played college football for the South Carolina Gamecocks, and was signed by the New York Giants as an undrafted free agent in 2014.
Quarles has also been a member of the New England Patriots, Indianapolis Colts, Cleveland Browns, Calgary Stampeders, Edmonton Eskimos, and Saskatchewan Roughriders.
As a junior in 2013, Quarles was a first-team All-Southeastern Conference (SEC) and second-team All-American selection.
On September 16, 2014, the Indianapolis Colts signed Quarles from the New England Patriots practice squad.
[6] The New England Patriots signed Quarles back to their practice squad on December 2, 2015.
[17] Quarles is the nephew of Patriots Hall of Fame tight end Ben Coates.