He committed to Clemson University to play college football under head coach Dabo Swinney.

[1] During Bryant's junior year of high school, he was unable to play in the first half of a game, as he was vomiting blood in the locker room.

Bryant was taken to the hospital and after an MRI, doctors found a large abscess blocking his lower intestine.

After Watson left for the 2017 NFL draft, Bryant was named Clemson's starting quarterback to open the 2017 season.

[5][6] Bryant led the Tigers to the 2017 ACC Championship, and a spot in the 2017 College Football Playoff, losing to eventual national champion Alabama in the Sugar Bowl.

On September 25, 2018, after week 4 of the 2018 season, coach Dabo Swinney announced that freshman Trevor Lawrence would be the new starting quarterback for the Tigers.

Bryant won the FCF People's Championship later that season and was named the game's MVP.