These dynamic players operated in a scheme that led the league in passing yards an NFL-record six consecutive seasons (1978–1983).

Zampese joined the St. Louis Rams in 2000 as an offensive assistant under head coach Mike Martz.

During his stint in St. Louis, Zampese assisted Martz with the passing game of what became known as "The Greatest Show on Turf" – a nickname for the Rams' high-powered, record-setting offense.

It was here that he gained additional exposure to the "3-Digit" passing system, pioneered by his father and expanded to new heights under Martz.

Quarterback Kurt Warner (and backups Trent Green and Marc Bulger), Hall of Fame RB Marshall Faulk, and WRs Isaac Bruce, Torry Holt, Az-Zahir Hakim and Ricky Proehl made up what is widely considered the most prolific offense in NFL history.

On September 15, 2017, Zampese was fired by the Bengals after the team started the season 0–2 and did not score a single touchdown.