He played college football for the NC State Wolfpack, and earned consensus All-American honors.

He was Prep Football Report All-America selection, adding all-state honors at Eastern Guilford High School in Gibsonville.

Additionally, Holt was a standout defensive back who posted 62 tackles and four interceptions as senior.

[2] After injuring his knee at the Senior Bowl, Holt, at 192 pounds, ran a 4.44 second 40-yard dash and had a vertical jump of 37 inches at the 1999 NFL Combine[6][7] Holt was the sixth overall draft pick in the 1999 NFL draft and the first selection made by the St. Louis Rams.

[9] In his rookie season, he posted 52 receptions, 788 total yards and six touchdowns on the way to the Super Bowl XXXIV championship.

[11] Holt's streak was broken in 2006, due to injuries to himself and other teammates that hindered the offense for parts of the season.

[20] He retired from professional football ranked 10th in league history with 13,382 yards receiving and 13th with 920 receptions.

[21] On November 20, 2010, during the Raycom Sports broadcast of the annual NCSU game with UNC-Chapel Hill, sideline reporter Mike Hogewood prefaced an interview with Holt stating that he had retired.

He made his debut as an analyst on the NFL Total Access: Pro Bowl Selection Show on December 28, 2010.

The brothers co-own Holt Brothers, Inc.. Beginning in 2015, Holt became Heritage High School's (NC) assistant football coach and wide receiver's coach, along with former NFL players Dewayne Washington and Willie Parker.