He is best known for his viral Dubsmash videos especially the song Twerk It Like Miley by Brandon Beal, thus naming him "The Philippines' King of Dubsmash," and his role as Pacoy Alvero in the afternoon's prime time drama Buena Familia on GMA Network and worldwide via GMA Pinoy TV.

He finished his high school education and taking up a bachelor's degree in Hotel and Restaurant Management at the University of Southern Philippines Foundation (USPF) in Lahug, Cebu City.

A compilation in which he impersonates the cartoon character Johnny Bravo, songs of One Direction, Akon, Backstreet Boys, High School Musical, Westlife, Air Supply, Black Eyed Peas, Justin Bieber, the song "I'm an Albatraoz" by AronChupa and "Lay Me Down" by Sam Smith, local celebrities like Julia Barretto, scenes from the movie Maybe This Time by Sarah Geronimo and Coco Martin, The Love Affair by Richard Gomez and Dawn Zulueta, One More Chance by John Lloyd Cruz and Bea Alonzo, Forevermore (TV series) by Enrique Gil and Liza Soberano and also he do the transformation video of a popular detergent soap in the Philippines.

He sings some of his favorite songs like "Kasalanan Ko Ba" by Neocolours, "Kunin Mo Na ang Lahat sa Akin" by Jeremiah and also he dances, all of the videos he posted online through social media.

Among all of his compilations, Medrano is the one who started to trend the dubsmash hit "Twerk It Like Miley" by Brandon Beal which he made went viral online with 2.6 million views overnight.

[1] Subsequently, Medrano recently posted his latest dubsmash version of Charlie Puth's song One Call Away on his Twitter account dedicated to all his fans.

[7] On 11 July 2015, Medrano joined That's My Bae: "Twerk It" Dance Contest[broken anchor], a segment on the longest running noontime show Eat Bulaga!

He joined with his fellow bae colleagues in the contest with Miggy Tolentino, Joel Palencia, Gab Bayan, Tommy Peñaflor, Jon Timmons and Kim Last.

In September 2015, Medrano was part of the supporting cast on which he portrays one of the protagonists, as Pacoy Alvero on afternoon's prime time Buena Familia on GMA Network.

He also appeared on a true to life love story drama on Wagas aired on GMA News TV which he portrays George, an ordinary poor unemployed man and security guard which is in love with a rich girl named Belle which portrayed by Kylie Padilla.

[1][12] In February 2016, he appeared on Eat Bulaga's segment KalyeSerye on which he portrayed the character named Pepito, a farmer and the cousin of young Anselmo which is one of Lola Nidora's love interests during her younger days in 1945.